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How to generate cyclic backbone with rfdiffusion2

Status: Open.

#49 In RosettaCommons/RFdiffusion2;

· breadbread1984 opened on May 27, 2026

Specific value of sigma_perturb used in Stochastic Centering

Status: Open.

#47 In RosettaCommons/RFdiffusion2;

· Wangchentong opened on Dec 19, 2025

Run the pipeline without container

Status: Open.

#46 In RosettaCommons/RFdiffusion2;

· giuliapeteani opened on Dec 10, 2025

Trying to run inference script

Status: Open.

#43 In RosettaCommons/RFdiffusion2;

· Valentin-Bio opened on Dec 1, 2025

Unexpected true atoms...

Status: Open.

#40 In RosettaCommons/RFdiffusion2;

· EvanKomp opened on Nov 14, 2025

Double Ligand Enzyme

Status: Open.

#38 In RosettaCommons/RFdiffusion2;

· alejandromontesa opened on Nov 13, 2025

AME Benchmark Clarification

Status: Open.

#33 In RosettaCommons/RFdiffusion2;

· proteinsRk00l opened on Oct 22, 2025

Chai prediction with ligands

Status: Open.

#29 In RosettaCommons/RFdiffusion2;

· BJHardy opened on Oct 16, 2025

The RFdiffusion2 paper claims that users can "specify the RASA of each atom" for fine control over ligand burial depth, but this feature is not implemented in the open source codebase? Only molecule-level RASA conditioning is available.

Status: Open.

#11 In RosettaCommons/RFdiffusion2;

· G-Armstrong opened on Sep 9, 2025